Acute methamphetamine exposure inhibits cardiac contractile function
نویسندگان
چکیده
منابع مشابه
Molecular remodeling of cardiac contractile function.
A number of techniques are now available that allow the contractile apparatus of the heart to be altered in a defined manner. This review focuses on those approaches that result in germ-line transmission of the remodeling event(s). Thus the desired modifications can be propagated stably throughout multiple generations and result in the creation of stable, new animal models. Necessarily, such st...
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OBJECTIVE The purpose of the present study was to determine whether increased activation of the RhoA/Rho-kinase (ROCK) pathway occurs in diabetic cardiomyopathy and whether acute inhibition of this pathway improves contractile function of the diabetic heart. METHODS Male Wistar rats were made diabetic with streptozotocin. Twelve to fourteen weeks later, the effects of acute administration of ...
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Results: Results demonstrated that OC treatment or nicotine exposure led to increased hemorheological (blood viscosity, hematocrit and plasma viscosity), prothrombotic (plasminogen activator inhibitor-1), proinfl ammatory (Creactive protein, uric acid, neutrophil/lymphocyte ratio and platelet/lymphocyte ratio) and anti-infl ammatory (corticosterone) markers. However, these effects except that o...
متن کاملDyssynchrony, contractile function, and response to cardiac resynchronization therapy.
BACKGROUND Despite benefits of cardiac resynchronization therapy (CRT) in patients with severe but less symptomatic heart failure, approximately 30% of patients do not fully respond to treatment. We hypothesized that a combined assessment of left ventricular (LV) dyssynchrony and contractile function by strain-based imaging would identify patients who would most benefit from CRT. METHODS AND ...
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Cardiac troponin I (cTnI) is a key regulatory protein in cardiac muscle contraction and relaxation, linking Ca(2+)-troponin C binding with activation of crossbridge reactions with the thin filament. In recent years, it has become increasingly apparent that myofilament properties as well as changes in intracellular Ca(2+) have a major role in the dynamic modulation of contractile function. The p...
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ژورنال
عنوان ژورنال: Toxicology Letters
سال: 2009
ISSN: 0378-4274
DOI: 10.1016/j.toxlet.2009.05.015